Runes can come from Runecrafters or from vendors that require there zone rep to buy.
The names of crafted runes go in this order: Abiding/Fine > Detailed/Exquisite> Improved/Phenomenal > Illustrious/Magnificent -- Illustrious and Magnificent being best in slot.

However the highest crafted runes for damage dealers is the Magnificent and Improved version.

Damage Dealer:
Magnificent Rune of Dexterity - Helmet
Magnificent Rune of Dexterity - Cape
Magnificent Rune of Dexterity - Shoulders
Magnificent Wrathful Rune - Chest
Magnificent Steadfast Rune - Gloves
Magnificent Steadfast Rune - Belt
Magnificent Wrathful Rune - Legs
Magnificent Intrepid Rune - Feet

Magnificent Weapon-rune of Dexterity - Main/Off Hand
Magnificent Weapon-rune of Dexterity - Range
Improved Bloodthirster's Abhorrent Rune - Earrings
Atragarian Deft Rune - Neck
Rhenke Deft Rune - Trinket
Magnificent Deft Rune - Rings
Shal Korva Imperium Rune - Seal
Pelagic Resistance Rune - Focus

Tank:
Illustrious Rune of Endurance - Helmet
Illustrious Rune of Endurance - Cape
Illustrious Rune of Endurance - Shoulders
Illustrious Hardy Rune - Chest
Illustrious Thwarting Rune - Gloves
Illustrious Thwarting Rune - Belt
Illustrious Hardy Rune - Legs
Illustrious Thwarting Rune - Feet

Illustrious Weapon-rune of Endurance - Main/Off Hand
Illustrious Weapon-rune of Endurance - Range
Improved Telluric Rune of Defense - Earrings
Atragarian Resolute Rune - Neck
Rhenke Resolute Rune - Trinket
Phenomenal Resolute Rune - Rings
Shal Korva Aegis Rune - Seal
Pelagic Resistance Rune - Focus

​

Currently the best Focus to use is Sigil of Striking for Damage Dealers and Sigil of Sanctuary for Tanks which is found within Intrepid Gilded Prophecy on Hardmode.

If this is unavailable then the next best is Focus of Nightmares, which is located in the Rift Store > Equipment > Focus.
 

Damage Dealer:
For your greaters you want the proc to increase your Crit Power, or if at CP Cap your Critical Hit, & Attack Power via damaging abilities.
The Attack Power one has 2 versions the only difference between the two is the secondary affect, 5% proc chance or 5s duration increase.

Generally you wouldn't go for the CP ones, CP becomes less important once you reach the softcap, you will gain loads in raids via buffs as well, so go for the AP ones, they will be more beneficial to you.

And for healers you want healing procs/ap essences.

Crit Power - Flamesource of the Malevolent
Critical Hit - Stonesource of the Cryptic
Attack Power - Stormsource of the Malevolent
Attack Power - Tidesource of the Malevolent

Tank:
For your greaters you want the proc to increase your Endurance, & apply an Shield onto you when you are hit.
Endurance - Stormsource of Revenants
Shield - Stonesource of Revenants

​

Dream Orbs! - Spreadsheet can be found here!